The effectiveness of ozone as a therapeutic alternative for treating bovine mastitis.

Abstract

The goal of this review was to assess the effectiveness of ozone as a therapeutic alternativefor bovine mastitis, considering its antimicrobial and anti-inflammatory propertiesin comparison to traditional antibiotic treatments. A review was conducted covering the period from 2000-2025, which included assays, field studies, theses, reviews, and scientific articles. The purpose of this review was to analyze the doses utilized, the routes of administration, and the clinical and bacteriological outcomes in both clinical and subclinical mastitis. The primary limitation noted was the inconsistency in the protocols used, particularly regarding doses, concentrations, application frecuency, and routes of administration. The use of local or intramammary ozonotherapy has been demonstrated to be as effecive as antibiotics in several studies. Its main advantages include the abscence of residues in milk, and low cost. However, further controlled research is needed to develop standarized protocols that can effectively implemented in veterinary practice.