Fec, CA5A and CLSTN2 genes and their function during sheep ovulation: a review.


Guadalupe A. Delgado-Tiburcio
Cesar Cortez-Romero
Arturo Pro- Martínez
José A. Hernández-Marín
Jaime Gallegos-Sánchez


genes, Fec, CA5A, CLSTN2, sheep.


Objective: To describe the function of Fec, CA5A and CLSTN2 genes during ovulation in ewes.

Design/methodology/approach: A search and analysis of scientific information related to Fec, CA5A and CLSTN2 genes in sheep was performed.

Results: Fec, CA5A and CLSTN2 genes are involved at the ovarian level; ewes carrying the first gene were found to have increased ovulation rate, folliculogenesis and granulosa cell differentiation. CA5A stimulates an increased follicular rate and plays an important role in pre-implantation. While CLSTN2 has activity in ovarian development and growth; it also has the ability to interact with other genes involved in follicular maturation, granulosa cell differentiation and development of the ovarian follicle.

Limitations on study/implications: Ewes carrying these genes increase the prolificacy rate in the flock.

Findings/conclusions: The expression of these genes acts synergistically in the ovulatory process, enhancing the ovulatory response by contributing to endocrine, paracrine and molecular synchronisation, so that the maturation of the oocyte occurs, leading to ovulation.

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